Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental myasthenia gravis. A murine system

P W Berman, J Patrick

    The Journal of Experimental Medicine
    |January 1, 1980
    PubMed
    Summary

    Mice immunized with acetylcholine receptors developed antibodies, with some experiencing paralysis resembling myasthenia gravis. Antibody levels did not predict paralysis, suggesting specific antibody types are key to disease induction.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Search for a two-Higgs-boson doublet using a simplified model in pp collisions at sqrt[s] = 1.96 TeV.

    Physical review letters·2014
    Same author

    Changes in extrinsic fluorescence intensity of the electroplax membrane during electrical excitation.

    The Journal of membrane biology·2013
    Same author

    The effect of interpolated motor activities in short-term motor memory.

    Journal of motor behavior·2013
    Same author

    Measurement of the bottom-strange meson mixing phase in the full CDF data set.

    Physical review letters·2012
    Same author

    Search for the standard model Higgs Boson produced in association with top quarks using the full CDF data set.

    Physical review letters·2012
    Same author

    Measurements of the top-quark mass and the tt cross section in the hadronic τ+jets decay channel at sqrt[s] = 1.96 TeV.

    Physical review letters·2012

    Area of Science:

    • Neuroimmunology
    • Autoimmune Diseases

    Background:

    • Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions.
    • Understanding the specific triggers for MG is crucial for developing targeted therapies.

    Purpose of the Study:

    • To investigate the induction of experimental autoimmune myasthenia gravis (EAMG) in mice.
    • To identify factors correlating with the development of EAMG.

    Main Methods:

    • Immunization of mice from eight inbred strains with Torpedo californica acetylcholine receptor (AChR).
    • Assessing antibody concentrations, reactivity with mouse AChR, and occurrence of muscular weakness/paralysis.
    • Utilizing the BC3H-1 mouse muscle cell line to study AChR degradation.

    Main Results:

    • 33% of immunized mice developed EAMG, with strain-dependent susceptibility.
    • Antibody concentration and reactivity did not correlate with paralysis.
    • Anti-AChR antibodies increasing AChR degradation were present in both myasthenic and non-myasthenic mice.

    Conclusions:

    • EAMG induction is not solely dependent on the presence of anti-AChR antibodies.
    • Specific antibody structures or specificities are likely required for EAMG development.
    • This mouse model offers a platform for studying the regulation of anti-AChR immune responses.

    Related Experiment Videos