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[Nitrogen balance during modified fasting (author's transl)]

J G Wechsler, H H Ditschuneit, P Malfertheiner

    Deutsche Medizinische Wochenschrift (1946)
    |January 11, 1980
    PubMed
    Summary
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    Protein-saving modified fasting (PSMF) significantly reduces protein loss compared to total fasting in obese patients. This method stabilizes nitrogen balance within weeks, making it a safer option for longer durations.

    Area of Science:

    • Metabolism and Nutrition
    • Clinical Nutrition
    • Weight Management

    Context:

    • Obesity management often involves caloric restriction, posing risks of lean body mass loss.
    • Total fasting can lead to significant protein and nitrogen depletion.
    • Protein-substituted modified fasting (PSMF) aims to mitigate these losses.

    Purpose:

    • To evaluate the efficacy of PSMF in preventing protein loss during a 4-week modified fasting period in obese patients.
    • To compare nitrogen and protein balance during PSMF versus total fasting.
    • To assess the long-term nitrogen balance stability of PSMF.

    Summary:

    • Twenty-seven obese patients underwent a 4-week modified fasting regimen with 33g daily protein substitution (egg-white base).
    • Nitrogen balance was negative in weeks 1-2, balanced in week 3, and positive in week 4, with a total 4-week loss of 70.7g N (442g protein).

    Related Experiment Videos

  • PSMF resulted in one-third the protein loss seen in total fasting (442g vs 1145g).

    • Impact:

    • PSMF demonstrates a substantial reduction in lean body mass loss compared to total fasting.
    • Nitrogen balance stabilizes by the third week of PSMF, suggesting suitability for extended use.
    • This approach offers a safer alternative for prolonged weight loss interventions in obese individuals.