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Related Experiment Videos

Urinary kallikrein in postobstructive diuresis

W Lawton, G O'Connor, J Nelson

    Investigative Urology
    |January 1, 1980
    PubMed
    Summary
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    Bilateral ureteral ligation (BUL) in rats significantly reduced kidney function but increased urinary kallikrein excretion per functioning nephron. This suggests the kallikrein-kinin system plays a role in managing post-obstruction salt and water loss.

    Area of Science:

    • Nephrology
    • Urology
    • Physiology

    Background:

    • Bilateral ureteral ligation (BUL) is a model for obstructive uropathy.
    • The kallikrein-kinin system (KKS) is involved in regulating renal function and blood pressure.

    Purpose of the Study:

    • To investigate urinary kallikrein excretion in rats following 24-hour BUL.
    • To explore the role of the KKS in post-obstructive renal dysfunction and salt/water imbalance.

    Main Methods:

    • Rats underwent 24-hour BUL or sham operation.
    • Glomerular filtration rate (GFR), urine flow rate, and fractional electrolyte excretion were measured.
    • Urinary kallikrein excretion was quantified and normalized to GFR and functioning nephrons.

    Main Results:

    Related Experiment Videos

    • BUL rats showed a 20% GFR compared to controls.
    • Urine flow and fractional sodium/potassium excretion were significantly elevated in BUL rats.
    • Urinary kallikrein excretion per functioning nephron increased threefold in BUL rats, despite overall excretion being halved.

    Conclusions:

    • Post-obstructive diuresis and natriuresis in rats are associated with increased urinary kallikrein excretion per functioning nephron.
    • The findings suggest a compensatory role for the kallikrein-kinin system in mitigating salt and water losses during obstructive uropathy.