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Cefazolin in children with renal insufficiency
The Journal of Pediatrics
|February 1, 1980
Insights
Cefazolin
Area of Science:
- Pharmacokinetics
- Pediatric Nephrology
Background:
- Renal insufficiency and hemodialysis significantly alter drug pharmacokinetics.
- Cefazolin is a commonly prescribed antibiotic in pediatric populations.
Purpose of the Study:
- To investigate the impact of renal insufficiency and hemodialysis on cefazolin pharmacokinetics in children.
- To establish appropriate cefazolin dosage recommendations for pediatric patients with impaired renal function.
Main Methods:
- Cefazolin (7 mg/kg) was administered to pediatric patients with varying degrees of renal function.
- Serum half-life and drug levels were monitored in children with renal insufficiency and those undergoing hemodialysis.
Main Results:
- Cefazolin's serum half-life increased as glomerular filtration rate decreased.
- Hemodialysis reduced cefazolin serum levels by 35-65%, often to undetectable levels before the next dialysis session.
Conclusions:
- Dosage adjustments for cefazolin are crucial in pediatric patients with renal insufficiency.
- Specific dosing guidelines are necessary for children undergoing hemodialysis to maintain therapeutic drug levels.
Abstract:
Cefazolin (7 mg/kg) were administered to 11 children with renal insufficiency and to ten children on hemodialysis. The serum half-life of the drug was progressively prolonged as glomerular filtration rate fell. The serum half-life of cefazolin was variably prolonged in those children on hemodialysis, but their serum levels of cefaxolin had dropped by 35 to 65% during dialysis. Most had no measurable level prior to the next dialysis. Dosage recommendations are made for both groups of patients.