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Ventilatory control in parents of victims of sudden-infant-death syndrome

P L Schiffman, R E Westlake, T V Santiago

    The New England Journal of Medicine
    |February 28, 1980
    PubMed

    Insights

    Parents of infants who died from sudden infant death syndrome (SIDS) show reduced ventilatory control. This suggests a potential genetic link in SIDS susceptibility, impacting respiratory drive and response to airway resistance.

    Area of Science:

    • * Physiology
    • * Genetics
    • * Pediatrics

    Background:

    • * Sudden infant death syndrome (SIDS) is a leading cause of post-neonatal mortality.
    • * Defective ventilatory control mechanisms are suspected contributors to SIDS.
    • * Hereditary factors are known to influence respiratory drive.

    Purpose of the Study:

    • * To investigate ventilatory responsiveness to carbon dioxide in parents of SIDS victims compared to controls.
    • * To assess the impact of added airway resistance on respiratory drive in these groups.
    • * To explore potential hereditary risk factors for SIDS.

    Main Methods:

    • * Measurement of ventilatory response (delta VI/delta PCO2) and respiratory drive (delta P100/delta PCO2) to carbon dioxide.
    • * Testing was conducted with and without added inspiratory flow resistance.
    • * Participants included 12 parents of SIDS victims and 12 matched control parents.

    Main Results:

    • * SIDS parents exhibited significantly lower ventilatory response to carbon dioxide, both with and without added resistance.
    • * SIDS parents showed significantly lower respiratory drive, particularly with added resistance.
    • * Control parents demonstrated increased respiratory drive with added resistance, unlike SIDS parents.

    Conclusions:

    • * A diminished ventilatory response to carbon dioxide may be a hereditary risk factor for SIDS.
    • * Reduced compensatory response to increased airway resistance in parents could indicate susceptibility.
    • * These findings suggest a potential genetic predisposition to SIDS in offspring of affected parents.

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