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Decrease of respiratory muscle strength and static lung volumes in obese asthmatics

E Melzer, J F Souhrada

    The American Review of Respiratory Disease
    |January 1, 1980
    PubMed
    Summary
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    Obese asthma patients with low total lung capacity (TLC) showed reduced respiratory muscle strength. This suggests obesity and steroid therapy may decrease respiratory muscle strength in some asthma patients.

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Steroid-dependent bronchial asthma often co-occurs with obesity.
    • Obesity can impact respiratory mechanics and lung volumes.

    Purpose of the Study:

    • To investigate the relationship between lung volumes and respiratory muscle strength in obese patients with asthma.
    • To determine if obesity and steroid therapy affect respiratory muscle function in this patient group.

    Main Methods:

    • Studied 10 obese, female, non-smoking asthma patients with normal chest X-rays.
    • Divided patients into groups based on total lung capacity (TLC): decreased TLC (N=4) and normal TLC (N=6).
    • Measured respiratory muscle strength via maximal inspiratory esophageal pressure and analyzed lung pressure-volume (P-V) curves.

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    Main Results:

    • Patients with decreased TLC exhibited reduced respiratory muscle strength.
    • Lung P-V curves were shifted downward and rightward in the low TLC group.
    • No significant differences were found in airflow limitation, weight gain, steroid dose, or duration between groups.

    Conclusions:

    • Respiratory muscle strength is crucial for maintaining normal static lung volumes.
    • Obesity combined with steroid therapy may lead to decreased respiratory muscle strength in some obese asthma patients.
    • Reduced static lung volumes may be secondary to decreased respiratory muscle strength, impacting lung P-V curves.