Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Restabilization with methadone after methadyl acetate maintenance

W Ling, M Blakis, E D Holmes

Archives of General Psychiatry

|February 1, 1980

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of ferritin heavy chain on oxidative stress, cell proliferation and apoptosis in geese follicular granulosa cells.

British poultry science·2024

Same author

Down-regulation of long non-coding RNA DUXAP8 suppresses proliferation, metastasis and EMT by modulating miR-498 through TRIM44-mediated AKT/mTOR pathway in non-small-cell lung cancer.

European review for medical and pharmacological sciences·2020

Same author

Associations of serum magnesium levels and calcium-magnesium ratios with mortality in patients with coronary artery disease.

Diabetes & metabolism·2019

Same author

Circulating retinol-binding protein 4 is associated with the development and regression of non-alcoholic fatty liver disease.

Diabetes & metabolism·2019

Same author

A polymorphism in the OPRM1 3'-untranslated region is associated with methadone efficacy in treating opioid dependence.

The pharmacogenomics journal·2016

Same author

Introducing this year's winners.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2016

Same journal

Reviewers Who Completed a Review During 2011.

Archives of general psychiatry·2017

Same journal

Conflicts of interest-reply.

Archives of general psychiatry·2013

Same journal

Epidemiologic evidence concerning the bereavement exclusion in major depression-reply.

Archives of general psychiatry·2013

Same journal

This month in archives of general psychiatry.

Archives of general psychiatry·2013

Same journal

About this journal.

Archives of general psychiatry·2013

Same journal

This month in archives of general psychiatry.

Archives of general psychiatry·2013

See all related articles

Patients switched from methadyl acetate to methadone can be stabilized. Adjusting methadone doses impacts illicit heroin use, suggesting a covert abstinence syndrome in long-term treatment.

Area of Science:

Addiction Medicine
Pharmacology

Background:

Opioid maintenance therapy is crucial for heroin addiction treatment.
Methadyl acetate and methadone hydrochloride are commonly used medications.

Purpose of the Study:

To assess the transition of heroin addicts from methadyl acetate to methadone.
To evaluate the impact of methadone dosage adjustments on illicit drug use and patient comfort.

Main Methods:

A double-blind study involving 68 heroin addicts over 40 weeks.
Patients were transferred to a uniform 60 mg daily methadone dose and observed for six weeks.
Methadone doses were adjusted based on clinical needs, monitoring for discomfort and illicit drug use.

Main Results:

Related Experiment Videos

Patients maintained on methadyl acetate were successfully restabilized on methadone.

Sudden methadone dose decreases correlated with increased illicit heroin use.

Increased methadone doses led to a reduction in illicit drug consumption.

Conclusions:

Methadone is effective for restabilizing patients previously on methadyl acetate.
Dosage titration is critical in managing illicit drug use during methadone maintenance.
A potential chronic covert abstinence syndrome may influence continued illicit drug use in long-term therapy.