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Related Experiment Videos

The systemic septic response: does the organism matter?

J B Wiles, F B Cerra, J H Siegel

    Critical Care Medicine
    |February 1, 1980
    PubMed
    Summary

    Septicemia, a severe bloodstream infection, triggers similar physiological responses regardless of the causative pathogen. The body

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    Area of Science:

    • Critical Care Medicine
    • Infectious Diseases
    • Cardiovascular Physiology

    Background:

    • Septicemia is a life-threatening condition with diverse etiologies.
    • Understanding the host response is crucial for effective management.
    • Previous studies often focused on specific microbial types.

    Purpose of the Study:

    • To comprehensively evaluate clinical and physiological responses in septicemia.
    • To compare responses across different causative microorganisms (gram-positive, gram-negative, anaerobes, fungi).
    • To elucidate the host-determined nature of the septic response.

    Main Methods:

    • Prospective study of 59 critically ill patients with 70 septic episodes.
    • Inclusion criteria: positive blood cultures and clinical infection.
    • Physiological assessment using dye dilution cardiac outputs.

    Main Results:

    • No significant differences in fever, leucocyte, or acid-base responses among organism groups.
    • Hyperdynamic cardiovascular response with abnormal vascular tone observed post-volume loading.
    • Myocardial depression was common across all septicemia types; heart rate increased cardiac output.
    • No statistical differences in physiological variables between specific organisms.

    Conclusions:

    • Septicemia elicits a consistent host response irrespective of the specific pathogen.
    • The observed cardiovascular and myocardial changes are characteristic of the host's reaction.
    • The pathogenesis of septic response is host-determined, not microbe-specific.

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