Related Experiment Video

Updated: Jul 30, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Desquamative interstitial pneumonitis in children

P C Stillwell, D G Norris, E J O'Connell

    Chest
    |February 1, 1980
    PubMed

    Insights

    Desquamative interstitial pneumonitis in children is a rare lung disease. Corticosteroid treatment showed a 61% survival rate in a review of 28 pediatric cases.

    Area of Science:

    • Pediatric Pulmonology
    • Rare Diseases
    • Interstitial Lung Diseases

    Background:

    • Interstitial pneumonitis in children is poorly understood, with ongoing debate about its classification.
    • Desquamative interstitial pneumonitis (DIP) is a specific form of this condition.

    Purpose of the Study:

    • To review biopsy-confirmed cases of desquamative interstitial pneumonitis in children.
    • To analyze clinical presentation, treatment outcomes, and associated conditions.

    Main Methods:

    • Retrospective review of 14 Mayo Clinic cases (1953-1975).
    • Literature search identifying an additional 14 cases, totaling 28 patients.
    • Analysis of clinical, radiographic, and laboratory findings.

    Main Results:

    • Common symptoms included growth retardation and dyspnea; tachypnea was the most frequent sign.
    • Chest X-rays consistently showed abnormal interstitial and alveolar patterns.
    • Corticosteroid treatment resulted in a 61% survival rate (17 of 28 patients).

    Conclusions:

    • Desquamative interstitial pneumonitis in children presents with specific clinical and radiographic features.
    • Corticosteroids appear to be a viable treatment option, though the disease's etiology remains unknown.
    • DIP can occur alongside other significant medical conditions.

    More Related Videos

    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease04:44

    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

    Published on: June 16, 2020

    Refined Murine Model of Idiopathic Pulmonary Fibrosis07:51

    Refined Murine Model of Idiopathic Pulmonary Fibrosis

    Published on: June 17, 2025

    Related Concept Videos

    Pulmonary Cycle: Exhalation01:17

    Pulmonary Cycle: Exhalation

    In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
    Pneumonia I: Introduction01:30

    Pneumonia I: Introduction

    Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
    Risk Factors
    Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
    Pneumothorax-II01:27

    Pneumothorax-II

    Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
    Clinical Manifestations:
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
    Chronic Obstructive Pulmonary Disease II: Emphysema01:23

    Chronic Obstructive Pulmonary Disease II: Emphysema

    Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
    Pneumonia I: Introduction01:29

    Pneumonia I: Introduction

    Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...