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Desquamative interstitial pneumonitis in children
Chest
|February 1, 1980
Summary
Desquamative interstitial pneumonitis in children is a rare lung disease. Corticosteroid treatment showed a 61% survival rate in a review of 28 pediatric cases.
Area of Science:
- Pediatric Pulmonology
- Rare Diseases
- Interstitial Lung Diseases
Background:
- Interstitial pneumonitis in children is poorly understood, with ongoing debate about its classification.
- Desquamative interstitial pneumonitis (DIP) is a specific form of this condition.
Purpose of the Study:
- To review biopsy-confirmed cases of desquamative interstitial pneumonitis in children.
- To analyze clinical presentation, treatment outcomes, and associated conditions.
Main Methods:
- Retrospective review of 14 Mayo Clinic cases (1953-1975).
- Literature search identifying an additional 14 cases, totaling 28 patients.
- Analysis of clinical, radiographic, and laboratory findings.
Main Results:
- Common symptoms included growth retardation and dyspnea; tachypnea was the most frequent sign.
- Chest X-rays consistently showed abnormal interstitial and alveolar patterns.
- Corticosteroid treatment resulted in a 61% survival rate (17 of 28 patients).
Conclusions:
- Desquamative interstitial pneumonitis in children presents with specific clinical and radiographic features.
- Corticosteroids appear to be a viable treatment option, though the disease's etiology remains unknown.
- DIP can occur alongside other significant medical conditions.
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