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Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
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Susceptibility of cutaneous propionibacteria to newer antibiotics

U Höffler, W Niederau, G Pulverer

    Chemotherapy
    |January 1, 1980
    PubMed

    Insights

    Newer antibiotics were tested against skin bacteria Propionibacterium species. Penicillin and cephalosporin antibiotics were effective, while aminoglycosides showed resistance and nitroimidazoles were ineffective.

    Area of Science:

    • Microbiology
    • Dermatology
    • Pharmacology

    Background:

    • Cutaneous propionibacteria, including Propionibacterium acnes, Propionibacterium granulosum, and Propionibacterium avidum, are common skin bacteria.
    • Understanding their susceptibility to antibiotics is crucial for treating related skin conditions.

    Purpose of the Study:

    • To determine the in vitro efficacy of 18 newer antibiotics against 33 strains of cutaneous propionibacteria.
    • To identify effective and ineffective antibiotic classes for these bacteria.

    Main Methods:

    • Minimal inhibitory concentrations (MICs) were determined for 18 antibiotics.
    • 33 strains of P. acnes, P. granulosum, and P. avidum were tested.

    Main Results:

    • All tested strains demonstrated high sensitivity to penicillin and cephalosporin antibiotics.
    • The bacteria exhibited significant resistance to aminoglycosides at therapeutically relevant concentrations.
    • Nitroimidazole compounds showed complete ineffectiveness against all tested strains.

    Conclusions:

    • Penicillin and cephalosporin antibiotics are promising for treating infections caused by cutaneous propionibacteria.
    • Aminoglycosides and nitroimidazoles are not recommended based on these in vitro findings.

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