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The chick as a model for malignant hyperpyrexia

A D Korczyn, S Shavit, I Shlosberg

    European Journal of Pharmacology
    |January 25, 1980
    PubMed
    Summary

    Succinylcholine causes rigid paralysis in chicks, potentially mimicking malignant hyperthermia. Drugs used for malignant hyperthermia protected chicks, suggesting chicks are a useful model for drug screening.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Animal Models

    Background:

    • Succinylcholine (SCh) induces rigid paralysis and mortality in chicks via respiratory impairment.
    • The mechanism is hypothesized to involve excessive intracellular calcium accumulation due to muscle fiber multiple innervation.
    • This physiological state resembles malignant hyperpyrexia (MH) in mammals.

    Purpose of the Study:

    • To investigate the potential of chicks as a model for studying succinylcholine-induced toxicity.
    • To evaluate the efficacy of drugs used to treat malignant hyperpyrexia in protecting against succinylcholine effects in chicks.

    Main Methods:

    • Administration of succinylcholine to chicks.
    • Treatment of chicks with dantrolene sodium, phenytoin, and procaine.
    • Observation of protective effects against SCh-induced rigidity and mortality.

    Main Results:

    • Dantrolene sodium, phenytoin, and procaine demonstrated protective effects against succinylcholine-induced rigidity and death in chicks.
    • The chick model showed promise for evaluating drug efficacy.

    Conclusions:

    • The chick serves as a viable and convenient model for the rapid screening of drugs potentially effective against succinylcholine-induced toxicity and possibly malignant hyperthermia.
    • Further research into this model could accelerate the development of novel therapeutic agents.

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