Sclerodermoid changes in a patient with metastatic malignant melanoma

A 55-year-old man with metastatic malignant melanoma suddenly developed sclerodermoid changes in association with a large metastasis on one side between neck and shoulder. Sclerodermoid changes are not commonly associated with visceral malignancies. We suggest that such cutaneous changes may result from immunologic phenomena related to rejection of malignancies, analogous to graft-versus-host reactions in which sclerodermoid changes are seen.