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Secondary products of itanoxone

J P Rieu, G Mouzin, H Cousse

Journal of Pharmaceutical Sciences

|January 1, 1980

Abstract:

Itanoxone synthesis by Friedel-Crafts reaction between itaconic anhydride and 2-chlorobiphenyl was studied. Five isomers corresponding to possible impurities were prepared and studied to perfect a reliable and practical method to detect these impurities in itanoxone.

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