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Related Concept Videos

Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.

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Related Experiment Video

Updated: Jun 26, 2026

A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
02:46

A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization

Published on: January 20, 2023

Bleomycin-induced diffuse interstitial pulmonary fibrosis in baboons

B McCullough, J F Collins, W G Johanson

    The Journal of Clinical Investigation
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Bleomycin causes lung inflammation and fibrosis in baboons, leading to lasting collagen and elastin increases. This animal model may mimic human idiopathic pulmonary fibrosis after lung injury.

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    A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis

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    Related Experiment Videos

    Last Updated: Jun 26, 2026

    A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
    02:46

    A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization

    Published on: January 20, 2023

    Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
    06:03

    Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

    Published on: May 9, 2025

    A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis
    05:45

    A Refined Aerosol-Based Intratracheal Bleomycin Delivery Method for Reproducible and Minimally Invasive Mouse Models of Pulmonary Fibrosis

    Published on: January 16, 2026

    Area of Science:

    • Pulmonary Medicine
    • Toxicology
    • Pathology

    Background:

    • Pulmonary fibrosis is a debilitating lung disease with poorly understood mechanisms.
    • Bleomycin is a chemotherapeutic agent known to induce lung injury and fibrosis in animal models.

    Purpose of the Study:

    • To investigate the temporal effects of bleomycin-induced lung injury and fibrosis in baboons.
    • To characterize the inflammatory and fibrotic responses in the baboon lung following bleomycin administration.

    Main Methods:

    • Pulmonary fibrosis was induced in baboons using bleomycin.
    • Lung function, lung volumes, and diffusing capacity were assessed.
    • Biochemical and histological analyses of lung tissue were performed.

    Main Results:

    • Bleomycin treatment reduced lung volumes and diffusing capacity, shifting pressure-volume curves.
    • Lung tissue showed increased weight, protein, collagen, elastin, and DNA, with elevated protein synthesis.
    • Survivors exhibited persistent increases in collagen and elastin concentrations despite near-normal histology.

    Conclusions:

    • Bleomycin induces an acute inflammatory response followed by connective tissue proliferation.
    • Resolution of inflammation leads to decreased tissue mass but persistent increases in collagen and elastin.
    • This baboon model may offer insights into idiopathic diffuse interstitial fibrosis in humans.