Related Experiment Video
Updated: Aug 17, 2026

Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
Published on: November 21, 2012
Pharmacological effects of p-chloroamphetamine with respect to current amine hypotheses of affective disorders
Abstract:
The effects of p-chloroamphetamine (pCA) on the regional distribution of dopamine, noradrenaline and 5-hydroxytryptamine in rat brain were studied at both 3 and 30 days after a single injection. It was found that pCA has no significant effect on the levels of dopamine or noradrenaline at either of the times studied. Conversely pCA had an effect on the levels of 5-hydroxytryptamine but the effect was both time and area dependent. pCA has been shown to be an effective antidepressant. Since the levels of 5-hydroxytryptamine were reduced in all areas studied and there was no effect on the levels of the two catecholamines, the results found in the study do not support an amine hypothesis in which these transmitters are implicated.
Related Concept Videos
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Drugs Affecting Neurotransmitter Release or Uptake
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Antipsychotic Drugs: Typical and Atypical Agents
Antidepressant Drugs: MAOIs and Other Agents

