[Structurally dependent effects of substituted thioureas on rna phage m 12 (author's transl)]

Using the agar diffusion method, thiourea as well as N-aryl-, N, N'-diaryl-, N-aryl-N'-alkyl-, N,N'-dialkyl-, and N-alkyl-substituted thiourea derivatives were examined for their effects on the system of Escherichia coli W 1665 F+/M 12. The compounds tested were found to produce more or less strongly inhibitive or promotive effects on the RNA phages and/or host bacteria. N-phenyl-N'-dibutyl thiourea, N-phenyl-N'-acetyl thiuorea, and N1,N1'-p-phenylene-bis-(N3-n-propyl thiourea) showed an intense inhibitory effect on M12. Quite obviously, the decisive intervention by these substances in the multiplication of viruses was by a replicative step subsequent to the adsorption of phages.