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Related Experiment Videos

Rat model for carcinogenesis in ureterosigmoidostomy

M M Crissey, G D Steele, R F Gittes

    Science (New York, N.Y.)
    |March 7, 1980
    PubMed
    Summary

    Urine diversion into the bowel causes colon cancer in rats. Blocking feces near the urine entry point prevents this cancer, suggesting urine or the bladder lining activates fecal carcinogens.

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    University of Chicago Pritzker School of Medicine.

    Academic medicine : journal of the Association of American Medical Colleges·2000

    Area of Science:

    • Urothelial carcinogenesis
    • Gastrointestinal oncology
    • Surgical oncology

    Background:

    • Ureterosigmoidostomy, a surgical procedure, diverts urine into the colon.
    • This procedure is associated with an increased risk of colon cancer.
    • The exact mechanism linking urine diversion to carcinogenesis remains unclear.

    Purpose of the Study:

    • To investigate the carcinogenic mechanisms of urine diversion into the fecal stream.
    • To identify the role of fecal matter and urothelium in ureterosigmoidostomy-induced colon cancer.

    Main Methods:

    • A rat model was utilized to simulate ureterosigmoidostomy.
    • Colon adenocarcinoma development was studied adjacent to the urine inlet.
    • The effect of proximal fecal diversion on carcinogenesis was assessed.

    Main Results:

    • Colon adenocarcinoma developed in rats with urine diverted into the fecal stream.
    • Tumor formation was observed adjacent to the urine inlet.
    • Proximal diversion of feces completely prevented adenocarcinoma development.

    Conclusions:

    • Urine diversion into the colon promotes local carcinogenesis.
    • Fecal carcinogens appear to be activated by urine or the urothelium.
    • Fecal diversion may be a preventive strategy against ureterosigmoidostomy-associated colorectal cancer.

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