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Effect of vitamin E supplementation on leukocyte function

J S Prasad

    The American Journal of Clinical Nutrition
    |March 1, 1980
    PubMed
    Summary
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    High-dose vitamin E (dl-alpha-tocopheryl acetate) supplementation in males depressed white blood cell bactericidal activity and lymphocyte transformation. However, skin-based immune responses remained unaffected by the vitamin E megadose.

    Area of Science:

    • Immunology
    • Nutritional Science
    • Biochemistry

    Background:

    • Vitamin E is a crucial fat-soluble antioxidant with known immunomodulatory effects.
    • The impact of high-dose vitamin E supplementation on specific immune functions, particularly in males, requires further elucidation.
    • Understanding these effects is vital for assessing potential benefits and risks of vitamin E megadosing.

    Purpose of the Study:

    • To investigate the effects of daily megadoses of vitamin E on immune parameters in adult males and young boys.
    • To assess the impact of vitamin E supplementation on leukocyte bactericidal activity and lymphocyte transformation.
    • To evaluate the effect on delayed hypersensitivity skin responses.

    Main Methods:

    • A study involving 13 adult males and five young boys.

    Related Experiment Videos

  • Daily administration of 300 mg of vitamin E (dl-alpha-tocopheryl acetate) for 3 weeks.
  • Measurement of leukocyte bactericidal activity, mitogen-induced lymphocyte transformation, and phytohemagglutinin skin hypersensitivity.

    • Main Results:

    • Significant depression in the bactericidal activity of leukocytes was observed.
    • Mitogen-induced lymphocyte transformation showed a significant decrease.
    • Delayed hypersensitivity skin reactions to phytohemagglutinin were not significantly affected by vitamin E supplementation.

    Conclusions:

    • Megadoses of vitamin E can suppress certain aspects of cell-mediated immunity, specifically leukocyte function and lymphocyte proliferation.
    • The discrepancy between in vitro and in vivo immune responses warrants further investigation.
    • Clinical implications regarding the use of high-dose vitamin E for immune modulation need careful consideration.