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Problems in paternity testing. Subtypes of AB

H A Perkins, P A Morel

    American Journal of Clinical Pathology
    |February 1, 1980
    PubMed
    Summary
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    Paternity testing revealed a potential discrepancy due to a mother

    Area of Science:

    • Forensic Serology and Genetics
    • Human Blood Group Genetics
    • Population Genetics

    Background:

    • Standard paternity testing relies on genetic markers, including blood group antigens.
    • The ABO blood group system, specifically the A1 and A2 subgroups, can present complexities in interpretation.
    • Previous studies suggest variations in ABO subgroup frequencies within different ethnic populations.

    Purpose of the Study:

    • To investigate a case of apparent non-paternity based on ABO blood typing results.
    • To explore the potential influence of weakened A1 gene expression in an A2B mother.
    • To examine the prevalence of A2B phenotypes in the Black population.

    Main Methods:

    • Performed standard paternity testing, including erythrocytic and HLA typing.

    Related Experiment Videos

  • Analyzed ABO blood group phenotypes, specifically focusing on A1, A2, and AB types.
  • Reviewed existing literature on ABO gene frequencies and phenotypes in diverse populations.

    • Main Results:

    • Initial paternity test results indicated non-paternity: A1 child, A2B mother, O father.
    • Subsequent erythrocytic and HLA typing strongly suggested the putative father's biological relationship.
    • Consideration of weakened A1 gene expression in the mother (A2B) provided a plausible explanation.

    Conclusions:

    • Apparent non-paternity in this case was likely due to the mother's A2B phenotype with a weakened A1 gene expression.
    • The findings highlight the importance of considering genetic variations and population-specific frequencies in paternity testing.
    • An increased prevalence of the A2B phenotype among Black individuals may warrant further investigation.