Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amniotic fluid thyroid hormone concentrations during human gestation

A H Klein, B E Murphy, R Artal

    American Journal of Obstetrics and Gynecology
    |March 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Development and Interrogation of a Transcriptomic Resource for the Giant Triton Snail (Charonia tritonis).

    Marine biotechnology (New York, N.Y.)·2021
    Same author

    Nanoclusters and nanolines: the effect of molybdenum oxide substrate stoichiometry on iron self-assembly.

    Nanotechnology·2017
    Same author

    Effect of maternal serum on viability and function of early human placental explants.

    In vitro cellular & developmental biology. Animal·2016
    Same author

    Thermosensitive transient receptor potential (TRP) channel agonists and their role in mechanical, thermal and nociceptive sensations as assessed using animal models.

    Chemosensory perception·2015
    Same author

    Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses.

    Neuroscience·2014
    Same author

    Atomically resolved STM imaging with a diamond tip: simulation and experiment.

    Nanotechnology·2013
    Same journal

    Trends in Infertility Treatments by Race, Ethnicity, Socioeconomic Status, and Region in U.S. Birth Certificates from Live Births: 2011-2022.

    American journal of obstetrics and gynecology·2026
    Same journal

    Likelihood ratios enhance clinical interpretation of metagenomic prediction of early-onset neonatal sepsis in preterm premature rupture of membranes (Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Taking risk stratification in preterm premature rupture of membranes to the bedside (Reply to Letter-to-the-Editor).

    American journal of obstetrics and gynecology·2026
    Same journal

    Gestational Age at Full-Term Delivery and Long-Term Offspring Morbidity in Low-Risk Pregnancies: A Population-Based Cohort Study.

    American journal of obstetrics and gynecology·2026
    Same journal

    Trajectories of childbirth-related posttraumatic stress symptoms after a vaginal delivery: a multicenter prospective study.

    American journal of obstetrics and gynecology·2026
    Same journal

    Early life adversity and polycystic ovary syndrome among North American pregnancy planners.

    American journal of obstetrics and gynecology·2026
    See all related articles

    Amniotic fluid thyroid hormone levels (AFT4, AFT3, and AFrT3) change throughout pregnancy, with AFT3 increasing later. These findings offer reference values for diagnosing fetal thyroid conditions.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Perinatal Medicine

    Background:

    • Thyroid hormones play a crucial role in fetal development.
    • Understanding the dynamic changes in amniotic fluid thyroid hormone concentrations during pregnancy is essential for assessing fetal well-being.

    Purpose of the Study:

    • To measure and characterize the concentrations of amniotic fluid thyroid hormones, specifically thyroxine (AFT4), triiodothyronine (AFT3), and reverse triiodothyronine (AFrT3), throughout gestation.
    • To establish normal reference ranges for these hormones to aid in the prenatal diagnosis of fetal thyroid abnormalities.

    Main Methods:

    • Samples were collected from pregnant women across a wide gestational range (10 to 43 weeks).
    • Concentrations of AFT4, AFT3, and AFrT3 were quantified using appropriate analytical techniques.

    Related Experiment Videos

    Main Results:

    • AFT4 and AFrT3 concentrations increased during the first half of pregnancy, peaking between 17-20 and 25-30 weeks, respectively.
    • AFT3 levels remained low and increased slowly in early pregnancy, but showed a continuous rise in the latter half.
    • AFT4 and AFrT3 levels decreased in the second half of pregnancy, while AFT3 continued to rise.

    Conclusions:

    • The observed patterns suggest a significant increase in fetal 5'-iodothyronine monodeiodinase activity during gestation.
    • The established normal values provide a valuable reference for the prenatal diagnosis of fetal thyroid dysfunction.
    • These findings contribute to a better understanding of thyroid hormone regulation in the feto-placental unit.