Management of acute chorioamnionitis

Area of Science:

• Obstetrics and Gynecology
• Maternal-Fetal Medicine
• Infectious Diseases in Pregnancy

Background:

• Acute chorioamnionitis poses significant risks to both mother and fetus.
• Limited research exists on effective therapeutic strategies for acute chorioamnionitis.

Purpose of the Study:

• To evaluate the management plan and outcomes for acute chorioamnionitis.
• To assess the impact of current therapeutic approaches on maternal and perinatal health.

Main Methods:

• Parenteral, broad-spectrum antibiotic therapy was administered.
• Prompt delivery was prioritized, with Cesarean section reserved for obstetric indications.
• No fixed time limit was imposed for the diagnosis-to-delivery interval.

Main Results:

• Over 90% of patients delivered within 12 hours of diagnosis.
• Perinatal mortality showed a fourfold increase, though few deaths were directly linked to infection.
• Maternal outcomes were favorable after vaginal delivery, but more complex after abdominal delivery.

Conclusions:

• The described management plan for acute chorioamnionitis, combining antibiotics and timely delivery, appears effective.
• While perinatal mortality is a concern, infection is not the primary cause in most cases.
• Vaginal delivery is associated with better maternal outcomes compared to Cesarean section in this context.