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[Cephalosporin C stability in aqueous solutions]
Antibiotiki
|February 1, 1980
Summary
The stability of cephalosporin C in water was analyzed across different temperatures. Zinc ions were found to have no significant impact on the cephalosporin C inactivation rate.
Area of Science:
- Pharmaceutical Chemistry
- Physical Chemistry
- Chemical Kinetics
Context:
- Cephalosporin C is a crucial antibiotic.
- Understanding its degradation is vital for drug formulation and storage.
- Aqueous solutions present common storage conditions.
Purpose:
- To investigate the stability of cephalosporin C in aqueous solutions.
- To determine the kinetic parameters of its inactivation.
- To evaluate the effect of zinc ions on stability.
Summary:
- Cephalosporin C stability was studied in aqueous solutions at various temperatures.
- Kinetic parameters for inactivation were determined across a wide pH range (0-12.5).
- Zinc ions did not exhibit a specific effect on the inactivation rate.
Impact:
- Provides critical data for optimizing cephalosporin C storage conditions.
- Informs pharmaceutical formulation strategies to enhance drug shelf-life.
- Contributes to the understanding of antibiotic degradation kinetics.