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Rhabdomyolysis during treatment with epsilon-aminocaproic acid
Archives of Neurology
|March 1, 1980
Summary
Epsilon-aminocaproic acid can cause direct muscle damage, leading to rhabdomyolysis and acute kidney injury. This drug may induce a range of muscle disorders, from mild myopathy to severe, life-threatening rhabdomyolysis.
Area of Science:
- Pharmacology
- Toxicology
- Nephrology
Background:
- Epsilon-aminocaproic acid is used to treat or prevent excessive bleeding.
- Muscle-related side effects of this drug are not well-documented.
Observation:
- A patient developed severe rhabdomyolysis and acute renal failure while on epsilon-aminocaproic acid therapy.
- Muscle biopsy showed no signs of vascular issues.
Findings:
- Epsilon-aminocaproic acid may possess direct myotoxicity.
- The drug can cause a spectrum of muscle diseases, including myopathy and rhabdomyolysis.
Implications:
- Clinicians should be aware of the potential for epsilon-aminocaproic acid-induced myotoxicity.
- Monitoring muscle enzymes may be warranted in patients receiving this medication.
- Further research is needed to elucidate the mechanisms of epsilon-aminocaproic acid myopathy.