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Intravenous histamine in otologic practice. Side effects in 2,347 administrations
Archives of Otolaryngology (Chicago, Ill. : 1960)
|March 1, 1980
Summary
Intravenous histamine treatment improved symptoms in 36% of patients with dizziness or sudden hearing loss. Side effects were rare and not serious, indicating a safe treatment option.
Area of Science:
- Otolaryngology
- Neurology
- Pharmacology
Background:
- Vasospasm is implicated in various medical conditions.
- Intravenous (IV) histamine has a 30-year history of use for vasospasm-related conditions.
- A large patient cohort received IV histamine treatment.
Purpose of the Study:
- To evaluate the efficacy and safety of IV histamine.
- To analyze treatment outcomes for dizziness and sensorineural hearing loss.
- To assess side effects associated with IV histamine administration.
Main Methods:
- Retrospective analysis of 2,347 IV histamine administrations.
- Data collected from 622 patients over a 33-month period.
- Indications included dizziness and sensorineural hearing impairments.
Main Results:
- 36% of patients experienced symptom improvement.
- Immediate improvement was observed in nearly half of those who responded.
- Side effects were uncommon, not serious, and unrelated to skin test results or medical history.
Conclusions:
- IV histamine is an effective treatment for certain conditions, particularly dizziness and sudden hearing loss.
- The treatment demonstrates a favorable safety profile with minimal adverse events.
- Further research may explore optimal patient selection and treatment protocols.
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