Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous activities in vivo

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Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.

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Related Experiment Videos

Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous

Related Concept Videos

Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.

Wealth of opportunity - the C1 domain as a target for drug development.

Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes.

Distinct features of recombinant rat vanilloid receptor-1 expressed in various expression systems.

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Related Experiment Videos

Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous...

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Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous