Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The pentose phosphate pathway in brain during development

A M Hakim, G Moss, D Scuderi

    Biology of the Neonate
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    IRMPD spectroscopy and quantum chemistry calculations on mono- and bi-metallic complexes of acetylacetonate ligands with aluminum, iron, and ruthenium ions.

    The Journal of chemical physics·2020
    Same author

    Outcomes from 18 years of cervical spine surgery in MPS IVA: a single centre's experience.

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2018
    Same author

    Tandem mass spectrometry and infrared spectroscopy as a tool to identify peptide oxidized residues.

    Physical chemistry chemical physics : PCCP·2015
    Same author

    Conformational analysis of quinine and its pseudo enantiomer quinidine: a combined jet-cooled spectroscopy and vibrational circular dichroism study.

    The journal of physical chemistry. A·2012
    Same author

    465 nm laser sources by intracavity frequency doubling using a 49-edge-emitters laser bar.

    Optics letters·2011
    Same author

    Chiral recognition in cinchona alkaloid protonated dimers: mass spectrometry and UV photodissociation studies.

    The journal of physical chemistry. A·2010
    Same journal

    Prevalence of two tumor necrosis factor gene polymorphisms in premature infants with early onset sepsis.

    Biology of the neonate·2006
    Same journal

    Can cerebrospinal fluid uric acid levels differentiate intraventricular hemorrhage from traumatic tap?

    Biology of the neonate·2006
    Same journal

    Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain.

    Biology of the neonate·2006
    Same journal

    Thymus involution and cerebral white matter damage in extremely low gestational age neonates.

    Biology of the neonate·2006
    Same journal

    Primary repair of esophageal atresia in extremely low birth weight infants: a single-center experience and review of the literature.

    Biology of the neonate·2006
    Same journal

    Systemic and pulmonary effects of vasopressors and inotropes in the neonate.

    Biology of the neonate·2006
    See all related articles

    The pentose phosphate pathway is highly active in developing rat brains, peaking at 3 days old. This suggests a crucial role in early brain development and nucleic acid synthesis.

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Developmental Biology

    Background:

    • The pentose phosphate pathway (PPP) is a critical metabolic route involved in producing NADPH and pentose sugars.
    • Understanding the developmental regulation of metabolic pathways in the brain is essential for comprehending neural development.

    Purpose of the Study:

    • To investigate the activity of the pentose phosphate pathway in the developing rat brain.
    • To determine the developmental trajectory of 6-phosphogluconate concentration and turnover rates in rat brain.

    Main Methods:

    • Quantification of 6-phosphogluconate concentrations in Sprague-Dawley rat brain extracts from 1 to 60 days of age.
    • In vitro determination of 6-phosphogluconate turnover rates at various developmental stages (1, 3, 12 days, and adult).

    Related Experiment Videos

    Main Results:

    • 6-phosphogluconate concentration was significantly elevated in young rats, with the highest levels observed at 3 days of age (over six times the adult level).
    • Turnover rates of 6-phosphogluconate also showed a developmental peak, correlating with the concentration findings.

    Conclusions:

    • The pentose phosphate pathway exhibits heightened activity in the developing rat brain compared to the adult brain.
    • A peak in PPP activity around 3 days of postnatal life suggests a potential role in supporting nucleic acid synthesis during rapid brain growth.