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Related Experiment Videos

Changes in multiple or sequential estrogen receptor determinations in breast cancer

J C Allegra, A Barlock, K K Huff

    Cancer
    |February 15, 1980
    PubMed
    Summary

    Estrogen receptor (ER) analyses in breast cancer are consistent across simultaneous biopsies. However, endocrine therapy significantly reduces ER levels, suggesting it eliminates ER-positive cells, while chemotherapy shows minimal impact on ER concentration over time.

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    Area of Science:

    • Oncology
    • Endocrinology
    • Cancer Biology

    Background:

    • Estrogen receptor (ER) analysis is crucial for breast cancer management.
    • Limited data exist on ER variations influenced by time and treatment.

    Purpose of the Study:

    • To investigate the concordance of ER analyses from simultaneous and serial biopsies.
    • To evaluate the impact of chemotherapy and endocrine therapy on ER levels over time.

    Main Methods:

    • Analysis of ER levels from multiple biopsies in breast cancer patients.
    • Comparison of ER results from simultaneous assays and serial assays over time.
    • Assessment of ER changes before and after hormonal therapy or chemotherapy.

    Main Results:

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  • Simultaneous ER assays from different metastatic sites showed 85% concordance.
  • ER concentrations remained stable over time in patients without intervening therapy.
  • Hormonal therapy led to a significant decrease in median ER concentration (66 to 8 fmol/mg protein, P < 0.05).
  • Chemotherapy did not significantly alter median ER concentrations.

    • Conclusions:

    • Simultaneous ER assays are reliable for breast cancer staging.
    • Endocrine therapy effectively reduces ER levels, indicating selective elimination of ER-positive cells.
    • Chemotherapy has a negligible effect on ER levels over time.