The influence of serum paraproteins on Burstein's reaction for beta-lipoproteins

Using sulfonated polysaccharides to precipitate beta-lipoprotein in serum, we obtained high values in certain cases with normal serum lipids. Therefore, we examined whether there are proteins in such sera which precipitate under conditions optimal for beta-lipoprotein insolubilization. The results show that certain IgG paraproteins are precipitable by sulfonated polysaccharides giving erroneously high values for beta-lipoprotein.