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Serum inorganic fluoride: changes related to previous fluoride intake, renal function and bone resorption
Clinical Science (London, England : 1979)
|February 1, 1980
Summary
Serum fluoride levels reflect intake and bone stores, influenced by kidney function and bone resorption. The body lacks direct homeostatic control over fluoride ion levels.
Area of Science:
- Biochemistry
- Nephrology
- Endocrinology
Background:
- Fluoride is an essential trace element with complex physiological interactions.
- Understanding fluoride homeostasis is crucial for managing fluoride toxicity and therapeutic applications.
Purpose of the Study:
- To investigate the factors influencing inorganic fluoride concentrations in human serum and urine.
- To determine the relationship between fluoride clearance, kidney function, and bone metabolism.
Main Methods:
- Analysis of serum and urine fluoride levels in 24 subjects on a low fluoride diet.
- Correlation of fluoride levels with creatinine clearance, parathormone, thyrocalcitonin, and markers of bone resorption.
Main Results:
- Serum fluoride correlated with prior intake and bone fluoride stores.
- Reduced fluoride clearance occurred below 25 ml/min creatinine clearance, increasing serum fluoride.
- Parathormone increased serum fluoride, while thyrocalcitonin decreased it, acting on bone.
- Elevated serum fluoride was observed in patients with chronic bone resorption, decreasing with successful treatment.
Conclusions:
- Serum fluoride concentration is sensitive to intake, kidney filtration, and bone resorption.
- The human body does not appear to exert direct homeostatic control over fluoride ion levels.