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The effect of dimethyl sulfoxide on tissue distribution of gentamicin
Experientia
|January 15, 1980
Abstract:
Dimethyl sulfoxide (DMSO) and getamicin were administered to rats i.p. No significant differences in gentamicin tissue concentrations were found between rats receiving DMSO and gentamicin, and rats receiving gentamicin alone. DMSO does not increase the tissue concentrations of gentamicin.
Insights
Dimethyl sulfoxide (DMSO) did not alter gentamicin tissue concentrations in rats. This study found no significant differences, indicating DMSO does not enhance gentamicin tissue uptake.
Area of Science:
- Pharmacology
- Toxicology
- Drug Interactions
Background:
- Gentamicin is an antibiotic requiring careful dosing to achieve therapeutic tissue concentrations.
- Dimethyl sulfoxide (DMSO) is a solvent with potential biological effects.
- Investigating co-administration of DMSO and gentamicin is crucial for understanding potential drug interactions.
Purpose of the Study:
- To determine if co-administration of Dimethyl sulfoxide (DMSO) affects gentamicin tissue concentrations in rats.
- To assess the impact of DMSO on the pharmacokinetic profile of gentamicin.
Main Methods:
- Rats were administered gentamicin intraperitoneally.
- One group received both gentamicin and DMSO intraperitoneally.
- Tissue concentrations of gentamicin were measured and compared between groups.
Main Results:
- No statistically significant differences in gentamicin tissue concentrations were observed between the group receiving DMSO and gentamicin and the group receiving gentamicin alone.
- Dimethyl sulfoxide (DMSO) did not lead to an increase in gentamicin tissue concentrations.
Conclusions:
- Dimethyl sulfoxide (DMSO) does not appear to increase gentamicin tissue concentrations when co-administered.
- These findings suggest that DMSO does not enhance the tissue distribution or accumulation of gentamicin in rats.