Clotting changes in two patients with longitudinal sinus thrombosis

Area of Science:

• Neurology
• Hematology
• Vascular Medicine

Background:

• Cerebral venous sinus thrombosis (CVST) is a rare condition with diverse etiologies.
• Understanding the prothrombotic states associated with CVST is essential for effective management.

Observation:

• Two patients with angiographically confirmed longitudinal sinus thrombosis were evaluated for coagulation abnormalities.
• Case 1 presented with significant primary thrombocytosis.
• Case 2 exhibited elevated fibrinogen and whole blood plasma viscosity.

Findings:

• The patient with thrombocytosis was treated with aspirin, dipyridamole, and radioactive phosphorus.
• The patient with elevated viscosity developed deep vein thrombosis and was managed with coumarin anticoagulation.
• These cases illustrate distinct hemostatic derangements in cerebral venous thrombosis.

Implications:

• A comprehensive coagulation assessment is vital in all patients diagnosed with cerebral vein thrombosis.
• Tailoring treatment based on specific coagulation profiles may improve patient outcomes.
• Further research into the prothrombotic mechanisms of CVST is warranted.