Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative cisternography

U Lying-Tunell

    Acta Radiologica: Diagnosis
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Quantitative cisternography reveals prolonged cerebrospinal fluid clearance in demented patients. Normalization of clearance after shunting in normal pressure hydrocephalus patients suggests treatment efficacy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Trace elements in the human central nervous system studied with neutron activation analysis.

    Biological trace element research·2013
    Same author

    Gait apraxia in normal-pressure hydrocephalus: patterns of movement and muscle activation.

    Neurology·1985
    Same author

    Chromosome analysis and sister chromatid exchange in encephalo-trigeminal angiodysplasia.

    Acta neurologica Scandinavica·1982
    Same author

    Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids.

    Acta neurologica Scandinavica·1981
    Same author

    Confusion, myoclonus and speech arrest: epileptic manifestations after metrizamide myelography.

    Acta neurologica Scandinavica·1981
    Same author

    Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids.

    Acta neurologica Scandinavica·1980

    Area of Science:

    • Neurology
    • Nuclear Medicine
    • Biomedical Engineering

    Background:

    • Cerebrospinal fluid (CSF) dynamics are crucial for brain health.
    • Abnormal CSF clearance is implicated in neurological disorders like dementia and hydrocephalus.
    • Quantitative cisternography offers a method to assess CSF elimination rates.

    Purpose of the Study:

    • To establish a reproducible method for measuring cerebrospinal fluid (CSF) clearance from basal cisterns.
    • To determine the normal range for biologic half time (BHT) of CSF clearance.
    • To investigate differences in CSF clearance between demented patients, normal pressure hydrocephalus (NPH) patients, and controls.

    Main Methods:

    • Quantitative cisternography using a stationary detector system with tissue background correction.

    Related Experiment Videos

  • Radioactive tracer 131I-HSA was used to measure elimination from basal cisterns.
  • Calculation of biologic half time (BHT) for CSF clearance curves.

    • Main Results:

    • Demonstrated exponential elimination of 131I-HSA from basal cisterns with reproducible BHT measurements.
    • Established a 'normal' range for BHT.
    • Demented patients exhibited significantly longer BHT compared to controls.
    • In NPH patients, prolonged BHT normalized post-shunting, correlating with clinical improvement.

    Conclusions:

    • Quantitative cisternography is a reproducible method for assessing CSF clearance and determining BHT.
    • Prolonged BHT is a potential biomarker for cognitive impairment and NPH.
    • Successful shunting in NPH normalizes CSF clearance and improves clinical outcomes.