Studies on a weakly immunogenic squamous cell carcinoma of the rat prostate

Different methods were tested to elicit and assess transplantation immunity against the weakly immunogenic 11095A squamous cell carcinoma, a methylcholanthrene-induced prostatic tumor of the inbred F344 rat strain. The results described emphasize the difficulty with which effective immune responses are induced by very weak transplantation antigens. The importance of using poorly immunogenic tumors as research models is discussed.