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Bizarre cutaneous neurofibromas

D T King, R J Barr

    Journal of Cutaneous Pathology
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Bizarre cutaneous neurofibroma is a rare benign skin tumor. Its unique microscopic features, including cellular pleomorphism, can be mistaken for malignancy, highlighting the need for careful diagnosis.

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    Area of Science:

    • Dermatopathology
    • Surgical Pathology
    • Oncology

    Background:

    • Cutaneous neurofibroma is a benign neoplasm originating from nerve sheath cells.
    • Bizarre cutaneous neurofibroma represents an uncommon variant with distinct histological features.
    • Accurate diagnosis is crucial to differentiate from malignant neoplasms.

    Observation:

    • Microscopic examination reveals stellate and polyhedral cells within a myxoid stroma.
    • Less commonly, solid sheets of epithelioid cells may be present.
    • Cellular pleomorphism and mitotic figures are common, potentially leading to misdiagnosis.

    Findings:

    • The myxoid material stains positive for sulfated mucosubstance, likely chondroitin sulfate B.
    • Histological features can mimic malignant tumors, necessitating expert evaluation.

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  • Previous terminology includes nerve sheath myxoma, Pacinian neurofibroma, myxoid neurofibroma, and neurotheceoma.

    • Implications:

    • Understanding the histological spectrum of bizarre cutaneous neurofibroma aids in accurate diagnosis.
    • Distinguishing this benign entity from malignancy prevents unnecessary aggressive treatment.
    • Further research into the specific mucosubstance may elucidate the tumor's biology.