Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urbach-Wiethe disease. Light and electron microscopic study

G Fabrizi, B Porfiri, M Borgioli

    Journal of Cutaneous Pathology
    |February 1, 1980
    PubMed
    Summary

    Lipoid proteinosis involves dermal infiltration of a unique granulo-filamentous substance. Fibroblasts synthesize this material, and endothelial cells react to its compression.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Artificial intelligence and future perspectives in Forensic Medicine: a systematic review.

    La Clinica terapeutica·2024
    Same author

    Clinical and Biological Aspects of Skin Aging.

    Indian journal of dermatology and venereology·2017
    Same author

    Not a simple plantar wart: a case of tungiasis.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2017
    Same author

    An under-recognized, life-threatening complication of atopic dermatitis.

    Clinical and experimental dermatology·2017
    Same author

    Role of DWI assessing nodal involvement and response to neoadjuvant chemotherapy in advanced breast cancer.

    European review for medical and pharmacological sciences·2017
    Same author

    Fusidic acid betamethasone lipid cream.

    International journal of clinical practice·2016

    Area of Science:

    • Dermatology
    • Pathology
    • Cell Biology

    Background:

    • Lipoid proteinosis is a rare genetic disorder characterized by hyaline deposition in the skin and other organs.
    • Understanding the cellular mechanisms underlying substance accumulation is crucial for potential therapeutic strategies.

    Observation:

    • Histologic examination of palpebral biopsies revealed extensive dermal infiltration by a granulo-filamentous material.
    • Electron microscopy demonstrated normal collagen fibers but highlighted significant changes around dermal capillaries.

    Findings:

    • Fibroblasts appear to be actively involved in synthesizing the accumulating substance in lipoid proteinosis.
    • Endothelial cells in dermal capillaries exhibited concentric multilamination of the basal lamina, likely a response to external compression.

    Implications:

    • These findings suggest a specific cellular response to the pathological deposition in lipoid proteinosis.
    • Further research into fibroblast activity and basal lamina changes may offer insights into disease pathogenesis and treatment.

    Related Experiment Videos