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Updated: Jul 13, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Preparation and biological actions of N-2,2,2-trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine
Abstract:
N-2,2,2,-Trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine was synthesized and compared to N-ethyl-2-(3,4-dihydroxyphenyl)-ethylamine and dopamine for activity on adenylate cyclase in the rat striatum. Both dopamine and N-ethyl-2-(3,4-dihydroxyphenyl)ethylamine stimulated adenylate cyclase activity in a dose-dependent fashion. The N-trifluoroethyldopamine analog at 1 x 10(-4) M induced a weak effect. The compounds were evaluated further by studying their relaxant effects in isolated rabbit renal and ear arteries. Both the N-ethyl- and N-trifluoroethyldopamine analogs produced a relaxant effect but demonstrated no selectivity for dopamine receptors.
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