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Updated: Aug 12, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Oral and rectal absorption of chloral hydrate and its betaine complex
Abstract:
Chloral hydrate and its betaine complex was administered orally and rectally to nine healthy male subjects. The urinary excretion, which was a reflection of absorption, of a metabolite, trichloroacetic acid, was determined. No statistically significant difference was found between the oral absorption of chloral hydrate and its betaine complex and between the rectal absorption of chloral hydrate and its betaine complex. A statistical difference was found between the oral and rectal absorption of chloral hydrate and between the oral and rectal absorption of chloral betaine.
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