Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural requirements for the sequestration of metabolically generated acetaldehyde

H T Nagasawa, J A Elberling, E G DeMaster

    Journal of Medicinal Chemistry
    |February 1, 1980
    PubMed
    Summary

    Certain aminothiols can sequester acetaldehyde in vitro, but only D-(-)-penicillamine effectively reduced blood acetaldehyde levels in vivo, highlighting the importance of pharmacokinetic factors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prevention of naphthalene-induced pulmonary toxicity by glutathione prodrugs: roles for glutathione depletion in adduct formation and cell injury.

    Journal of biochemical and molecular toxicology·2005
    Same author

    Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues.

    Chemico-biological interactions·2001
    Same author

    Cigarette smoke-induced endothelium dysfunction: role of superoxide anion.

    Journal of hypertension·2001
    Same author

    N-hydroxybenzenecarboximidic acid derivatives: a new class of nitroxyl-generating prodrugs.

    Nitric oxide : biology and chemistry·2001
    Same author

    Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues.

    Chemico-biological interactions·2001
    Same author

    Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen.

    Biochemical pharmacology·2001

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Medicinal Chemistry

    Background:

    • Acetaldehyde (AcH) is a toxic metabolite of ethanol metabolism.
    • Developing effective AcH-sequestering agents is crucial for managing alcohol-related conditions.

    Purpose of the Study:

    • To evaluate the in vitro and in vivo efficacy of polyfunctional compounds in sequestering acetaldehyde.
    • To identify key structural and pharmacokinetic factors influencing AcH sequestration.

    Main Methods:

    • In vitro testing of various polyfunctional compounds for acetaldehyde sequestration at pH 7.5.
    • In vivo studies in rats treated with disulfiram and ethanol to assess blood acetaldehyde levels.

    Main Results:

    • Several 1,2- or 1,3-disubstituted aminothiols demonstrated in vitro acetaldehyde sequestration.

    Related Experiment Videos

  • Only D-(-)-penicillamine effectively lowered in vivo blood acetaldehyde levels in rats.

    • Conclusions:

    • Acetaldehyde sequestration efficacy depends on both molecular functionality and pharmacokinetic/metabolic factors.
    • D-(-)-penicillamine shows promise as an in vivo acetaldehyde-lowering agent.
    • Further research is needed to optimize AcH-sequestering agents for therapeutic use.