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Tissue pH electrodes for clinical applications

D K Harrison, W F Walker

    Journal of Medical Engineering & Technology
    |January 1, 1980
    PubMed
    Summary
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    Researchers developed a new skin pH microelectrode to measure tissue perfusion. This device shows promise for assessing peripheral vascular disease and monitoring intensive care patients.

    Area of Science:

    • Biomedical Engineering
    • Clinical Measurement
    • Physiology

    Background:

    • Reduced peripheral blood flow in shock or arterial disease increases tissue hydrogen ion activity.
    • Measuring this change could indicate tissue perfusion status.
    • Existing microelectrodes are unsuitable for clinical skin pH monitoring.

    Purpose of the Study:

    • To develop a novel microelectrode for clinical measurement of extracellular skin pH.
    • To assess the feasibility of using skin pH as an indicator of tissue perfusion.

    Main Methods:

    • Investigated various pH microelectrode designs.
    • Tested antimony and externally insulated glass microelectrodes, finding them unsatisfactory.
    • Developed and tested an internally insulated glass microelectrode with a glass-to-glass fuse.

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    Main Results:

    • The internally insulated microelectrode was robust, stable, sensitive, and fast-responding.
    • Reproducible skin pH values were obtained in normal volunteers.
    • Preliminary patient results suggest applicability in peripheral vascular disease and intensive care.

    Conclusions:

    • A novel, clinically feasible skin pH microelectrode was successfully developed.
    • The microelectrode can provide reproducible measurements in vivo.
    • This technology holds potential for assessing peripheral perfusion and patient monitoring.