Nasal sarcoidosis with septal perforation

Area of Science:

• Otorhinolaryngology
• Pulmonology
• Dermatology

Background:

• Systemic sarcoidosis is a multisystem granulomatous disease.
• Nasal manifestations can be the initial presentation of sarcoidosis.
• Treatment of nasal sarcoidosis often involves corticosteroids.

Observation:

• A patient with systemic sarcoidosis presented with nasal symptoms.
• Nasal symptoms persisted despite septal reconstruction and systemic corticosteroid therapy.
• Anterior septal perforation developed during methylprednisolone treatment.

Findings:

• Beclomethasone dipropionate inhaler provided significant relief from nasal symptoms.
• Topical corticosteroid therapy may be effective for nasal sarcoidosis when systemic treatments fail.
• Nasal septal perforation is a potential complication of corticosteroid treatment in sarcoidosis.

Implications:

• Inhaled corticosteroids represent a viable therapeutic option for nasal sarcoidosis.
• Careful monitoring is necessary during systemic corticosteroid treatment for sarcoidosis.
• Early diagnosis and tailored treatment are crucial for managing sarcoidosis with nasal involvement.