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Related Experiment Videos

Bladder involvement in hereditary angioedema

R C Van Dellen, R P Myers

    Mayo Clinic Proceedings
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Hereditary angioedema (HAE) can affect the bladder, causing gross hematuria. Bladder lesions in HAE patients resolved with improved disease control, suggesting a link between HAE activity and urinary symptoms.

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    Area of Science:

    • Urology
    • Immunology
    • Genetics

    Background:

    • Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent swelling episodes.
    • While HAE commonly affects the skin, gastrointestinal tract, and upper airway, bladder involvement is infrequently reported.

    Observation:

    • A male patient with a history of hereditary angioedema experienced recurrent episodes of gross hematuria.
    • Cystoscopic examination revealed hemorrhagic lesions in the bladder wall, consistent with submucosal edema.
    • Biopsy confirmed edema without significant mucosal changes.

    Findings:

    • The study documents bladder involvement in hereditary angioedema, presenting as hemorrhagic lesions.
    • These lesions demonstrated submucosal edema on biopsy.

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  • Resolution of bladder lesions was observed following improved control of hereditary angioedema episodes.

    • Implications:

    • This case highlights the potential for hereditary angioedema to manifest in the urinary tract.
    • It suggests that bladder symptoms in HAE patients may be directly related to underlying disease activity.
    • Effective management of HAE may lead to the resolution of associated bladder complications.