One thousand consecutive midtrimester amniocenteses

Area of Science:

• Medical Genetics
• Prenatal Diagnosis
• Obstetrics

Background:

• Amniocentesis is a common prenatal diagnostic procedure.
• Accurate chromosome determination is crucial for identifying fetal abnormalities.

Purpose of the Study:

• To evaluate the reliability and safety of amniocentesis for prenatal diagnosis.
• To assess the accuracy of cytogenetic analysis in detecting serious fetal abnormalities.

Main Methods:

• 1000 pregnant women underwent amniocentesis.
• Chromosome determinations were performed by experienced specialists.
• Pregnancy outcomes were monitored throughout gestation and delivery.

Main Results:

• Amniocentesis was performed with minimal risk in this experienced center.
• Cytogenetic diagnoses were highly reliable.
• 21 pregnancies were terminated due to detected serious fetal abnormalities.
• Post-termination investigations confirmed the accuracy of all cytogenetic diagnoses.

Conclusions:

• Amniocentesis is a safe and reliable method for prenatal diagnosis of chromosomal abnormalities.
• Accurate cytogenetic analysis via amniocentesis supports informed reproductive decision-making.
• Experienced centers enhance the safety and reliability of prenatal diagnostic procedures.