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One thousand consecutive midtrimester amniocenteses

F K Bartsch, J Lundberg, J Wahlström

    Obstetrics and Gynecology
    |March 1, 1980
    PubMed
    Summary
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    Prenatal diagnosis using amniocentesis is reliable for detecting fetal abnormalities. Chromosome analysis following amniocentesis accurately identified serious genetic conditions, enabling informed decisions for 1000 women.

    Area of Science:

    • Medical Genetics
    • Prenatal Diagnosis
    • Obstetrics

    Background:

    • Amniocentesis is a common prenatal diagnostic procedure.
    • Accurate chromosome determination is crucial for identifying fetal abnormalities.

    Purpose of the Study:

    • To evaluate the reliability and safety of amniocentesis for prenatal diagnosis.
    • To assess the accuracy of cytogenetic analysis in detecting serious fetal abnormalities.

    Main Methods:

    • 1000 pregnant women underwent amniocentesis.
    • Chromosome determinations were performed by experienced specialists.
    • Pregnancy outcomes were monitored throughout gestation and delivery.

    Main Results:

    • Amniocentesis was performed with minimal risk in this experienced center.

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  • Cytogenetic diagnoses were highly reliable.
  • 21 pregnancies were terminated due to detected serious fetal abnormalities.
  • Post-termination investigations confirmed the accuracy of all cytogenetic diagnoses.

    • Conclusions:

    • Amniocentesis is a safe and reliable method for prenatal diagnosis of chromosomal abnormalities.
    • Accurate cytogenetic analysis via amniocentesis supports informed reproductive decision-making.
    • Experienced centers enhance the safety and reliability of prenatal diagnostic procedures.