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Changes in thyroid function tests during danazol therapy

R L Graham, R D Gambrell

    Obstetrics and Gynecology
    |March 1, 1980
    PubMed
    Summary
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    Danazol treatment for endometriosis can alter thyroid function tests, showing decreased thyroxine and elevated triiodothyronine uptake. However, patients remain euthyroid, indicating no true thyroid dysfunction.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine

    Background:

    • Danazol, a synthetic steroid, is used to treat endometriosis, particularly in infertile women.
    • Thyroid function was not extensively studied before danazol's clinical use in 1976.

    Purpose of the Study:

    • To investigate the effects of danazol on thyroid function in patients with endometriosis.
    • To determine if danazol therapy leads to clinical hypothyroidism.

    Main Methods:

    • Observational study of 8 patients receiving 800 mg of danazol daily for 1-5 months.
    • Monitoring of thyroid function tests, including TSH, T3 uptake, total T4, and FTI.

    Main Results:

    • All patients exhibited laboratory evidence of altered thyroid function.

    Related Experiment Videos

  • Elevated T3 uptake and decreased total serum T4 were observed.
  • Thyroid-stimulating hormone (TSH) and free thyroid index (FTI) remained normal, indicating euthyroid status.

    • Conclusions:

    • Danazol therapy causes laboratory changes in thyroid function tests but does not induce hypothyroidism.
    • These alterations are likely due to danazol's androgenic effect, reducing thyroxine-binding protein levels.