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Related Experiment Videos

Circulating immune complexes in patients with neoplastic disorders

R Yoshida, Z A Zawadzki

    Oncology
    |January 1, 1980
    PubMed
    Summary

    Researchers investigated circulating immune complexes in cancer patients using two radioimmunoassays. Findings suggest different types of immune complexes may be present in neoplastic disorders, impacting diagnostic accuracy.

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    Precision measurement and interpretation of inclusive

    The European physical journal. C, Particles and fields·2018

    Area of Science:

    • Immunology
    • Oncology
    • Radioimmunoassay

    Background:

    • Circulating immune complexes (CICs) are implicated in various diseases, including neoplastic disorders.
    • Accurate detection of CICs is crucial for understanding disease pathogenesis and progression.

    Purpose of the Study:

    • To evaluate the presence and quantity of CICs in patients with neoplastic disorders.
    • To compare the efficacy of two radioimmunoassays: the 125I-Clq inhibition test and the 125I-mRF inhibition test.

    Main Methods:

    • Sera from 100 patients with neoplastic disorders and 25 healthy subjects were analyzed.
    • The 125I-Clq inhibition test and 125I-mRF inhibition test were employed to detect CICs.

    Main Results:

    • The 125I-Clq inhibition test detected CICs in 32% of cancer patients.
    • The 125I-mRF inhibition test detected CICs in 23% of cancer patients.
    • A notable discrepancy was observed between the two assays in cancer patient sera.

    Conclusions:

    • The observed discrepancy suggests the potential presence of quantitatively different types of CICs in neoplastic disorders.
    • Further research is warranted to elucidate the specific types and clinical significance of CICs in cancer.

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