[Effect of castration on carbohydrate metabolism]

The effect of ovariectomy in the female albino rats on the content of glucose, glycogen, and on the activity of some metabolic enzymes of these substrates in the liver was studied. Ovariectomy in pubertal female rats led to reduction of the glucose and glycogen level in the liver. The glucokinase activity was significantly decreased during the whole period after ovariectomy. The activity of the enzymes taking part in glucose-6-phosphate-glucoso-phosphate-isomerase and aldolase decomposition also decreased. Glucose-6-phosphatase and fructose-1,6-diphosphatase activity was significantly elevated in the liver of ovariectomized rats.