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Drug-specific antibodies in human serum?
In view of the fact that all drugs possess the potential to stimulate an immunological response when administered to man, it was proposed that certain individuals in the general population may have developed high antibody titres to certain commonly used drugs. Human serum samples were incubated with radioactively-labelled drugs and the amount of IgG antibody present was determined by coprecipitation. Using the method outlined, we were unable to detect any antibodies specific for acetylsalicylic acid, ampicillin, erythromycin, lidocaine, penicillin, procainamide or tetracycline, and conclude that drug-specific immunoglobulins are not one of the major factors involved in the equilibrium between the free and bound drug forms.
In view of the fact that all drugs possess the potential to stimulate an immunological response when administered to man, it was proposed that certain individuals in the general population may have developed high antibody titres to certain commonly used drugs. Human serum samples were incubated with radioactively-labelled drugs and the amount of IgG antibody present was determined by coprecipitation. Using the method outlined, we were unable to detect any antibodies specific for acetylsalicylic acid, ampicillin, erythromycin, lidocaine, penicillin, procainamide or tetracycline, and conclude that drug-specific immunoglobulins are not one of the major factors involved in the equilibrium between the free and bound drug forms.