Hepatic friction rub in uremia

Hepatic friction rubs developed in two patients undergoing maintenance hemodialysis. Thorough evaluation, including autopsy in one patient, did not demonstrate any known cause for the rubs except that uremic pericarditis had complicated the course of both patients and one suffered from chronic hemolytic anemia. The clinical course suggests that hepatic friction rubs may be associated with either uremia or maintenance hemodialysis.