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Related Experiment Videos

Renal involvement in human trichinosis

V Sitprija, M Keoplung, V Boonpucknavig

    Archives of Internal Medicine
    |April 1, 1980
    PubMed
    Summary

    Trichinosis can cause kidney problems like glomerulonephritis. Kidney function and urinary abnormalities in patients with trichinosis improved after treatment.

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    Area of Science:

    • Nephrology
    • Infectious Diseases
    • Pathology

    Background:

    • Trichinosis is a parasitic infection that can affect various organs.
    • Renal involvement in trichinosis is uncommon but has been reported.
    • Understanding the clinicopathologic features of renal trichinosis is important for diagnosis and management.

    Purpose of the Study:

    • To investigate the clinicopathologic findings of renal involvement in patients with trichinosis.
    • To characterize the renal lesions and their resolution after treatment.

    Main Methods:

    • Retrospective analysis of five patients with confirmed trichinosis and renal abnormalities.
    • Clinical data collection including urinalysis, renal function tests (creatinine clearance, p-aminohippurate clearance), and serum albumin levels.
    • Renal biopsy examination with light microscopy, immunofluorescence, and electron microscopy.

    Main Results:

    • Patients presented with mild proteinuria and abnormal urinary sediment, which resolved post-treatment.
    • Renal biopsy revealed mesangial proliferative glomerulonephritis with immunoglobulin and C3 deposition.
    • Arteriolar hyaline material and C3 deposition were observed; tubular interstitial changes were absent.

    Conclusions:

    • Trichinosis can induce mesangial proliferative glomerulonephritis.
    • Renal lesions in trichinosis appear reversible with disease control.
    • Clinicopathologic correlation is crucial for managing renal manifestations of trichinosis.

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