Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cephalosporin-associated colitis and Clostridium difficile

S T Donta, G M Lamps, R W Summers

    Archives of Internal Medicine
    |April 1, 1980
    PubMed
    Summary

    Cephalosporin antibiotics can cause colitis. This study identified a toxin in patient feces linked to Clostridium difficile, suggesting its role in antibiotic-associated colitis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Randomised clinical trial: the safety and tolerability of Trichuris suis ova in patients with Crohn's disease.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Glutamate dehydrogenase is highly conserved among Clostridium difficile ribotypes.

    Journal of clinical microbiology·2012
    Same author

    Clostridium difficile prevalence rates in a large healthcare system stratified according to patient population, age, gender, and specimen consistency.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2011
    Same author

    Oral rehydration for viral gastroenteritis in adults: a randomized, controlled trial of 3 solutions.

    JPEN. Journal of parenteral and enteral nutrition·2006
    Same author

    Trichuris suis therapy in Crohn's disease.

    Gut·2004
    Same author

    Clinical testing of gastrointestinal motor function: introduction and process.

    Neurogastroenterology and motility·2002

    Area of Science:

    • Microbiology
    • Gastroenterology
    • Clinical Medicine

    Background:

    • Antibiotic-associated colitis is a significant clinical concern.
    • Cephalosporins are frequently implicated in causing colitis.
    • The specific microbial agents responsible for antibiotic-associated colitis are not always definitively identified.

    Observation:

    • A patient presented with cephalosporin-associated colitis.
    • Fecal samples from the patient exhibited tissue culture morphologic-altering activity during the active colitis episode.
    • This activity suggested the presence of a biologically active agent in the patient's gut.

    Findings:

    • The observed tissue culture activity was neutralized by antiserum against a partially purified toxin from Clostridium difficile.
    • This neutralization strongly suggests that Clostridium difficile toxin was responsible for the observed activity.
    • The findings provide a direct link between Clostridium difficile and the patient's cephalosporin-associated colitis.

    Implications:

    • This case highlights the importance of considering Clostridium difficile in antibiotic-associated colitis.
    • Identifying specific toxins can aid in diagnosing and understanding the pathogenesis of colitis.
    • Further research into Clostridium difficile toxins may lead to targeted therapeutic strategies.

    Related Experiment Videos